佟海滨-金沙检测线路js69

佟海滨-金沙检测线路js69
金沙检测线路js69-金沙9001cc以诚为本
硕导风采

个人简介

佟海滨,“吉林省青年科技奖”获得者,原就职于北华大学医学部生命科学研究中心,于2017年加入温州大学生命与环境科学学院,副研究员,硕士研究生导师,“瓯江特聘教授”d类。毕业于东北师范大学细胞生物学专业,获理学博士学位(导师:曾宪录教授),中国中医科学院中药资源中心接受博士后科研训练(合作导师:黄璐琦院士),国家留学基金委资助赴美国耶鲁大学进行为期一年的合作研究(合作导师:martin schwartz教授)。课题组重点开展特色药用生物资源(海洋藻类及道地中药材)天然活性物质的药理功能评价,主要针对非感染性炎症、慢性代谢性疾病等严重威胁人类健康的重大疾病,利用细胞及模式动物(小鼠、果蝇)模型,筛选发现天然先导化合物,在分子细胞及整体水平上揭示其药理药效机制,拓展药用生物新资源。

工作以来主持国家自然科学基金面上项目、青年基金、吉林省科技厅重点科技攻关项目、浙江省自然科学基金面上项目、中国博士后科学基金面上资助、吉林省科技厅优秀青年基金、温州市科技局重大科技创新攻关医疗卫生项目、吉林省教育厅、卫生厅、吉林市及温州市科技局项目多项。发表sci收录论文50余篇,其中第一及通讯作者30篇,他引900余次。国家自然科学基金通讯评审专家,美国化学会、wiley、elsevier、springer出版集团等多个国际学术期刊审稿人。获得吉林省自然科学奖二等奖1项,科技进步二等奖2项,申报及授权国家发明专利7项。荣获首批“吉林省高校科研春苗人才”以及“吉林市青年科技创新创业人才”称号。2016年获得“吉林省青年科技奖”。

指导的硕士研究生获国家奖学金、浙江省优秀毕业生等荣誉;与加拿大北哥伦毕业大学、韩国全南国立大学联合指导博士研究生。

近五年主持科研项目:

1. 羊栖菜岩藻聚糖硫酸酯干预高脂高糖膳食诱导胰岛素抵抗的功效评价及新型糖类先导物的发现(项目编号:zy2019013),温州市重大科技创新攻关医疗卫生项目

2. 柴胡中基于p-selectin靶点治疗急性肺损伤的新型糖类先导化合物的发现与作用机制研究(项目编号:81872952),国家自然科学基金面上项目

3. 传统中药柴胡拮抗黏附分子靶点用于治疗‎ali‎的新‎型糖类先导物的挖掘与药效评价‎(项目编号:y20180210),温州市科技计划项目

4. 羊栖菜多糖功能性糖链基序基于p-selectin靶点发挥急性肺损伤保护作用的机制研究(项目编号:ly18c020006),浙江省自然科学基金面上项目

5. 柴胡多糖拮抗p-选择素发挥急性肺损伤保护作用的研究(项目编号:2017m610155),中国博士后科学基金第61批面上资助一等

6. c-abl激酶在中性粒细胞应答剪切力爬行进程中的分子行为及作用机制研究(项目编号:31401203),国家自然科学基金青年项目

7. 基于p-selectin功能拮抗的柴胡多糖核心糖链基序的纯化及新型糖类抗炎药物开发(项目编号:20140204039yy),吉林省科技厅重点科技攻关项目

近五年代表性论文:

1. song, j.x., wu, y., ma, x.j., feng, l.j., wang, z.g., jiang, g.q.*,tong, h.b.*structural characterization and α-glycosidase inhibitory activity of a novel polysaccharide fraction fromaconitum coreanum.carbohydrate polymers, 2020,230, 115586.(sciif6.0442topcorresponding author

2. he, d., yan l.p., ma, x.j., cheng, y., wu, s.y., zuo, j.h., park, e.j., liu, j., wu, m.j., choi, j.i.*,tong, h.b.*gamma-irradiation degradation of sulfated polysaccharide from a new red alga strainpyropia yezoensissookwawon 104 and their in vitro antitumor bioactivity.oncology letters, 2020, in press(sciif1.8714区,corresponding author

3. liu, j., wu, s.y., chen, l., li, q.j., shen, y.z., jin, l., zhang, x., chen, p.c., wu, m.j.*, choi, j.i*,tong, h.b.*different extraction methods bring about distinct physicochemical properties and antioxidant activities ofsargassum fusiformefucoidans.international journal of biological macromolecules, 2019,doi:10.1016/j.ijbiomac.2019.11.113(sciif4.7842区,corresponding author

4. luthuli, s., wu, s.y., cheng, y., zheng, x.l., wu, m.j.*,tong, h.b.*therapeutic effects of fucoidan: a review on recent studies.marine drugs, 2019, 17, e487.(sciif3.7722区,corresponding author

5. song, j.x., wu, y., jiang, g.q., feng, l.j., wang, z.g., yuan, g.x.*,tong, h.b.*sulfated polysaccharides fromrhodiola sachalinensisreduce d-gal-induced oxidative stress in nih 3t3 cells.international journal of biological macromolecules, 2019,140, 288–293.(sciif4.7842区,corresponding author

6. he, d., wu, s.y., yan, l.p., zuo, j.h., cheng, y., wang, h.f., liu, j., zhang, x., choi, j.i., wu, m.j.*,tong, h.b.*antitumor bioactivity of porphyran extracted frompyropia yezoensischonsoo2 on human cancer cell lines.journal of the science of food and agriculture, 2019, 99: 6722–6730.(sciif2.4222topcorresponding author

7. cheng, y., sibusiso, l., hou, l.f., jiang, h.j., chen, p.c., zhang, x., wu, m.j.*,tong, h.b.*sargassum fusiformefucoidan modifies the gut microbiota during alleviation of streptozotocin-induced hyperglycemia in mice.international journal of biological macromolecules, 2019, 131: 1162-1170.(sciif4.7842区,corresponding author

8. wu, s.y., zhang, x., liu, j., song, j.x., yu, p., chen, p.c., liao, z.y., wu, m.j.*,tong, h.b.*physicochemical characterization ofsargassum fusiformefucoidan fractions and their antagonistic effect against p-selectin-mediated cell adhesion.international journal of biological macromolecules, 2019, 133: 656-662.(sciif4.7842区,corresponding author

9.tong, h.b., wu, s.y., song k.x., liu j., song x.d., zhang x., huang l.q.*, wu, m.j.* characterization of a p-selectin-binding moiety from bupleurum chinense polysaccharide and its antagonistic effect against p-selectin-mediated function.carbohydrate polymers, 2018, 196: 110-116.(sciif6.0442top

10.tong, h.b., zheng, x.l., song, j.x., liu, j., ren, t., zhang, x., huang, l.q.*, wu, m.j.*radical scavenging activity of sulfatedbupleurum chinensepolysaccharides and their effects against oxidative stress-induced senescence.carbohydrate polymers, 2018, 192: 143-149.(sciif6.0442top

11.tong, h.b., qi, d.k., guan, x.g., jiang, g.q., liao, z.y., zhang, x., chen, p.c., li, n., wu, m.j.* c-abl tyrosine kinase regulates neutrophil crawling behavior under fluid shear stress via rac/pak/limk/cofilin signaling axis.journal of cellular biochemistry,2018,119:2806–2817.(sciif3.4483

12. song, x.f., ren, t., zheng, z., lu, t.c., wang, z.c., du, f.g.,tong, h.b.*anti-tumor and immunomodulatory activities induced by an alkali-extracted polysaccharide bcap-1 frombupleurum chinensevia nf-κb signaling pathway.international journal of biological macromolecules, 2017, 95: 357-362.(sciif4.7842区,corresponding author

13.tong, h.b., jiang, g.q., qi, d.k., bi, j.f., tian, d., guan, x.g., zheng, s., sun, x.*bupleurum chinensepolysaccharide inhibit adhesion of human melanoma cells via blocking β1 integrin function.carbohydrate polymers, 2017, 156: 244-252.(sciif6.0442top

14.tong, h.b., jiang, g.q. guan, x.g., wu, h., song, k.x., cheng, k., sun, x.* characterization of a polysaccharide fromrosa davuricaand inhibitory activity against neutrophil migration.international journal of biological macromolecules, 2016, 89: 111-117.(sciif4.7842

15.tong, h.b., mao, d.r., zhai, m.y., zhang, z.r., sun, g.r., jiang, g.q.*macrophage activation induced by the polysaccharides isolated from the roots ofsanguisorba officinalis.pharmaceutical biology, 2015, 53: 1511-1515.(sciif1.9164

16.tong, h.b., song, j.x., zhang, z.r., mao, d.r., sun, g.r., jiang, g.q. inhibitory function of p-selectin-mediated leukocyte adhesion by the polysaccharides fromsanguisorba officinalis.pharmaceutical biology, 2015, 53: 345-349.(sciif1.9164

17.tong, h.b., tian, d., li, t.b., wang, b., jiang, g.q. sun, x. inhibition of inflammatory injure by polysaccharides frombupleurum chinensethrough antagonizing p-selectin.carbohydrate polymers, 2014, 105:20-25.(sciif6.0442top

18. kong, f.l., li, f.e., he, z.m.,, jiang, y., hao, r.y., sun, x.,tong, h.b.*anti-tumor and macrophage activation induced by alkali-extracted polysaccharide frompleurotus ostreatus.international journal of biological macromolecules, 2014, 69:561–566.(sciif4.7842区,corresponding author

授权发明专利

1.一种北柴胡多糖片段的纯化工艺及其在制备抗炎药物中的应用zl201610151866.1

2.山竹果皮花色苷的提取方法及其在制备抗炎药物中的应用zl 2010 1 0132394.8

3.一种高纯度松茸多糖提取工艺zl 2011 1 0072492.1

获奖情况

1.吉林省科技进步奖,二等奖,2019(第二完成人)

2.吉林省青年科技奖2016年

3.吉林省自然科学奖,二等奖,2015(第二完成人)

4.吉林省科技进步奖,二等奖,2013(第二完成人)

联系电话 13819706331(短号676331)

电子邮箱 tonghaibin@gmail.com tonghb@wzu.edu.cn

 

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